脂质体胶囊可延长吗啡镇痛时间

作者：佚名来源：互联网通发布时间：2007-8-3 8:50:47

Body art from the West, male body is mainly a reflection of the strength of the United States. While the female body is mainly a reflection of the kind of a female-specific negative of tender.

Body art is static human form, does not contain sexual intercourse is exposed genitals or other to tease of limb movements. Good photographs focus on the human body is the use of light and shadow. The body was

naked from the arts, the human body art is not carnal desire , vulgar. Accurately speaking, and now, the "body art" is not very precise. Art classification is based on the auditory,

摘要：将吗啡包裹于脂质体球形颗粒制成的胶囊内，不仅可延长镇痛时间，而且药物副作用减少。(Anesth Analg 2000;91(2):423-428)

发表在麻醉和镇痛痛杂志（Anesthesia and Analgesia）上的一项研究表明，将吗啡包裹于脂质体球形颗粒制成的胶囊内，不仅可延长镇痛时间，而且药物副作用减少。日本的Nishiyama及其研究小组解释道，“脂质体可以作为缓释载体，使脊柱存放大剂量的鸦片，限制全身系统很快摄取。”

Nishiyama通过鼠慢性腰椎鞘内导管研究脂质体包裹吗啡的效应，脂质体由两种同分异构磷脂-左旋和右旋二棕榈油磷脂酰胆碱(L- and D-DPPC)组成。尽管脂质体胶囊包裹吗啡的50%有效量较大，（L-DPPC为4.6 μg，D-DPPC 为6.4 μg，而生理盐水吗啡为2.7μg ），但研究人员发现，两种脂质体胶囊吗啡镇痛时间显著延长。除此之外，与对照组相比，注射脂质体胶囊吗啡组副作用显著减少。

Nishiyama等总结道，“用L-DPPC 和D-DPPC包裹的吗啡与普通吗啡相比，其对于急性热刺激疼痛的镇痛时间延长，副作用减少。”

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